ea0022p443 | Endocrine tumours & neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010
Gahete Manuel D
, Cordoba-Chacon Jose
, Hergueta Marta
, Gracia-Navarro Francisco
, Kineman Rhonda D
, Moreno-Bueno Gema
, Luque Raul M
, Castano Justo P
Ghrelin has been classically known as a GH- and metabolism-regulating hormone, mainly produced by stomach. However, it also acts as a paracrine or autocrine factor in several tissues, where it can regulate tissue growth and neoplastic cell proliferation. Of note, ghrelin needs to be acylated at Ser3 by the ghrelin-O-acyltransferase (GOAT) enzyme to bind to its receptor GHS-R1a. Interestingly, the ghrelin gene can give rise to distinct additional peptides, generated by alternat...